Bubbling up on more than 100 islands in a lagoon off the Adriatic, Venice is an absolutely unique and unquestionably beautiful city. Step into Piazza San Marco, an airy expanse of arches, sunlight, and pigeons. The multi-domed Basilica on one end, completed in 1094 but decorated for centuries afterward, is the final resting place of the apostle St. Mark, Venice’s patron saint. The mosaics beneath the basilica’s outside arches depict the arrival of St. Mark’s body, stolen from Egypt in 828 by Venetian traders. The frothy Venetian Gothic Doge’s Palace stands next door. Continue on to a glass-blowing demonstration. Venetian glass has long been considered the best in the world, and its production was such a state secret that during the Middle Ages, any Venetian glassblower who attempted to ply his trade outside the city was immediately arrested.

Stroll through St. Mark's Square. Bordered by Venice's greatest historic buildings, St. Mark's Square is the center of both the city and its water transportation system, as well as a popular tourist attraction.

Enjoy a visit to the Doge's’ Palace, residence of the rulers of the Serenissima Republic. We will explore the ornate and grandiose rooms of the palace, including a walk across thefamous Bridge of Sighs to the cells, where Casanova was once imprisoned, as well as the Grand Council chamber, featuring Tintoretto's Paradise, said to be the world's largest oil painting.

Brush up on your Shakespeare before heading to Casa de Giuletta to gaze up (or down from, for a few euros more) the famed balcony that set the stage for star-crossed lovers Romeo and Juliet. Hear about the many versions of this tragic story that existed long before Shakespeare put his pen to it. Go from this battleground of love to a real gladiator’s Roman Arena. Theatre performances still take place in this third largest amphitheater in all of Italy, built in the 1st century B.C.

Immerse yourself in the charms of old-world Firenze. The birthplace and focal point of the Italian Renaissance, Florence still has the masterpieces to prove it. Brunelleschi’s monumental cuploa (dome) atop the city's renowned Duomo dominates the skyline. Your local licensed guide will take you to Giotto's Bell Tower and the aptly named Gates of Paradise, the bronze east doors of the Baptistery that spurred the burgeoning Renaissance. Don’t overlook the tombs of Michelangelo, Galileo, and Machiavelli at the Chiesa di Santa Croce, or Florence’s amazing leather goods. You can check them out when you visit one of the area’s famed workshops!

Spend time in the Piazza della Signoria, the political stage of Renaissance Florence and an open-air museum of sculpture.

Stroll along the Ponte Vecchio, the oldest of Florence's six bridges and one of the best-loved sites of Florence. Lined with numerous shops, visitors often do not realize they are on a bridge until the reach the center arches that look out over the Arno.

The ultimate symbol of Ancient Rome, the Colosseum still dominates the modern city. Tour the amphitheater with your local licensed guide. Built by the emperor Vespasian in A.D. 72, the structure held almost 50,000 spectators but was so well organized that the entire place could be emptied within 15 minutes. Inside, the spectacles varied from gladiator battles to immense naval contests to wild beast shows, in which thousands of exotic animals like giraffes and ostriches were popped into the stadium through trap doors and left to fight Roman hunters. See the system beneath the floor that operated the trap doors and housed the animals, then continue on to the relative calm of the Forum. Ancient Rome’s commercial, religious and political center, the Forum held markets, temples and the Senate House. Near the Rostra, or speaker’s platform, you can still see game boards scratched into the marble by bored politicians--anyone up for a game of tic tac toe?

Tour the ruins and excavations of the Roman Forum, which features the remains of magnificent temples, basilicas, and triumphal arches that once formed the heart of the Empire.

Visit St. Peter’s Basilica where from the outside, the church has four rows of columns that radiate out like welcoming arms; inside, the church seems enormous enough to embrace the entire world. The dome, partially designed by Michelangelo, rises 452 feet above the ground. Michelangelo’s mark is everywhere here, from the costumes worn by the Swiss Guards to his exquisite “Pietà” sculpture (the only sculpture he ever signed) to the amazing frescoes of the Sistine Chapel. Because he considered himself a sculptor and not a painter, Michelangelo hated working on these paintings, now considered masterpieces.

Take a walk past Rome's most beautiful and unusual Baroque fountains. At the foot of the Spanish Steps, elegant cafes surround the central fountain. The water pressure here was so low that the artist had to sink the fountain into the ground to get any water going through it, so he went ahead and designed the fountain to look like a sinking ship. There's no shortage of water pressure at the nearby Trevi Fountain, a Baroque extravagance designed by master sculptor Bernini.

View the Trevi Fountain, where it is traditional to toss a coin into the fountain to ensure a safe return to the Eternal City.

We will spend some time in the Piazza Navona area. Built on the foundations of Domitian's Circus, this magnificent square was designed by Borromini in 17th century. It is full of life and is highlighted by one of Rome's most spectacular fountains, the Four Rivers designed by Bernini. The square is often filled with local artists. The surrounding neighborhood is also one of the best places in Rome to get a tasty tartufo or gelato ice cream