Immerse yourself in the charms of old-world Firenze, a red-brick splendor set in the rolling green hills of Tuscany. The birthplace and focal point of the Italian Renaissance, Florence still has the masterpieces to prove it. Brunelleschi’s elegant Duomo (dome) dominates the skyline, and around every corner is an architectural triumph filled with wall after wall of incomparable art. Your local licensed guide will take you to Giotto's Bell Tower and the aptly named Gates of Paradise, the bronze east doors of the Baptistery that spurred the burgeoning Renaissance. The boy guarding the Palazzo Vecchio with his slingshot is just a copy of Michelangelo’s David; the real statue is over at the Accademia. Don’t overlook the tombs of Michelangelo, Galileo, and Machiavelli at the Chiesa di Santa Croce, and definitely don’t overlook Florence’s amazing leather goods. Check them out when you visit one of the area’s famed workshops.

In fair Verona shall we lay our scene. The setting for Shakespeare’s “Romeo and Juliet” still glows with romance. See Juliet’s balcony, tenderly draped with climbing ivy and overlooking a golden-hued statue of the young mistress herself. As you gaze out and contemplate the power of love, don’t get too swept away -- remember that while Shakespeare based his characters on Verona’s real-life feuding families, both Romeo and Juliet were, in fact, fictional.

Brush up on your Shakespeare before heading to Casa de Giuletta to gaze up (or down from, for a few euros more) the famed balcony that set the stage for star-crossed lovers Romeo and Juliet. Hear about the many versions of this tragic story that existed long before Shakespeare put his pen to it. Go from this battleground of love to a real gladiator’s Roman Arena. Theatre performances still take place in this third largest amphitheater in all of Italy, built in the 1st century B.C.

Bubbling up on more than 100 islands in a lagoon off the Adriatic, Venice is an absolutely unique and unquestionably beautiful city. The weight of its opulent architecture – bulbous domes, gothic spires, and lacy marble – may be sinking the city by 10 inches a century, but your local guide will make sure you don’t sink out of sight as you tour the intricate labyrinth of streets and bridges. Step into Piazza San Marco, an airy expanse of arches, sunlight, and pigeons. The multi-domed Basilica on one end, completed in 1094 but decorated for centuries afterward, is the final resting place of the apostle St. Mark, Venice’s patron saint. The mosaics beneath the basilica’s outside arches depict the arrival of St. Mark’s body, stolen from Egypt in 828 by Venetian traders. The frothy Venetian Gothic Doge’s Palace stands next door. Continue on to a glass-blowing demonstration. Venetian glass has long been considered the best in the world, and its production was such a state secret that during the Middle Ages, any Venetian glassblower who attempted to ply his trade outside the city was immediately arrested.

A small town of narrow streets and medieval walls, Assisi might never have been famous had it not been the birthplace of St. Francis, the founder of the Franciscan order. Today it is a major destination for religious pilgrims and art lovers alike. You’ll explore the Basilica of St. Francis, built in the 13th century to hold the saint’s body. Ironically, the body was hidden so well in the basilica that it took 600 years of digging to find it.

Pope Gregory IX laid the first stone of the Lower Basilica the day after the canonization of St Francis, on July 17, 1228. Two years later the saint's body, that had been resting in the church of San Giorgio (the future church of St Claire's) was brought here in secret for fear of looting by tomb raiders and buried in the unfinished church. No date has been recorded concerning the start of works on the Upper Basilica, but it must have been after the abdication from the order of Brother Elia in 1239, who had hitherto directed the works on the Romanesque Lower Basilica. Both churches were consecrated by Pope Innocent IV in 1253.

Baroque-en hearted? Revive your spirits with a walk past Rome's most beautiful and unusual Baroque fountains. At the foot of the Spanish Steps, elegant cafes once favored by visiting Brits and Americans surround the central fountain. The water pressure here was so low that the artist had to sink the fountain into the ground to get any water going through it, so he went ahead and designed the fountain to look like a sinking ship. There's no shortage of water pressure at the nearby Trevi Fountain, a Baroque extravagance designed by master sculptor Bernini. At the Pantheon, you'll see the largest concrete dome ever constructed. An oculus, or hole, in the dome lets sunlight into the beautiful temple, dedicated to all the gods.

Gods and gladiators, glory and gore. Ancient Rome lives on in its spectacular monuments, flavoring the frenetic present with tastes of the past. Don a space-age Whisper headset to get the inside scoop on the most spectacular, the Colosseum, a grisly battle arena that seated more than 45,000. An enormous retractable roof awning system kept spectators cool on sunny days. The nearby Forum provides a glimpse into everyday ancient life, with markets, meeting places, and temples all combined into one vast space. Move into Christian Rome at St. Peter’s Basilica, the triumphal Renaissance church flanked by rows of columns radiating outward like welcoming arms. Within the church Michelangelo’s masterpieces are on display, the “Pietà” in the main church and the recently restored ceiling frescoes and “Last Judgment” in the Sistine Chapel. Continue your trek through time at Piazza Venezia, site of the enormous monument to Victor Emmanuel II, Italy’s first king, and of the Palazzo Venezia, where Mussolini set up his headquarters and from whose porch his mother was said to eavesdrop on citizens below. (The Sistine Chapel is closed on most religious holidays and Sundays, except for the last Sunday in each month).